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Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

Nature
Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested...
40 months ago

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Nature
We report reproductive tract EVs transmit information regarding stress in the paternal environment to sperm, potentially altering fetal development.
54 months ago

Dysregulated miR-124 mediates impaired social memory behavior caused by paternal early social isolation

Nature
Early social isolation (SI) leads to various abnormalities in emotion and behavior during adulthood. However, the negative impact of SI on...
1 week ago

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Nature
Here, we find that transcription factor Forkhead box protein N1 (FOXN1) responds to high population density and activates the polypyrimidine tract-binding...
4 months ago

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

Nature
We report that subchronic CORT treatment of male breeders reduced their week-on-week body weight gain and altered NR3C1 and CRH gene expression in the...
48 months ago

A next-generation sequencing study on mechanisms by which restraint and social instability stresses of male mice alter offspring anxiety-like behavior

Nature
Pathophysiological mechanisms for depression/anxiety are largely unknown. Evidence for transgenerational transmission of acquired epigenetic...
41 months ago

Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress | Translational Psychiatry

Nature
Exposure of male mice to early life stress alters the levels of specific sperm miRNAs that promote stress-associated behaviors in their offspring.
76 months ago

Life experiences of boars can shape the survival, aggression, and nociception responses of their offspring

Frontiers
IntroductionBoars are often housed in stressful environments on commercial farms, experiencing poor welfare. These conditions may cause epigenetic changes...
3 months ago

Cardiorenal metabolic biomarkers link early life stress to risk of non-communicable diseases and adverse mental health outcomes

Nature
We show that early life stress permanently programs metabolic pathways in somatic organs linked to cardiorenal and mental health disorders in later life.
50 months ago

Exposure to childhood abuse is associated with human sperm DNA methylation | Translational Psychiatry

Nature
Offspring of persons exposed to childhood abuse are at higher risk of neurodevelopmental and physical health disparities across the life...
72 months ago